Sibutramine (Reductil or Meridia) is an anorectic or appetite suppressant, reducing the desire to eat. 1 Definition. Compare. Der Arznei­wirkstoff Sibutramin wurde bis 2010 als Appetitzügler (Anorektikum) zur Reduktion von starkem Übergewicht (Adipositas) verwendet. Int J Obes Relat Metab Disord, 2002, 26, Suppl 4, S38-41 Pubmed ; Poston W.S., Foreyt J.P. Sibutramine and the management of obesity. [17], Sibutramine is a monoamine reuptake inhibitor (MRI) that, in humans, reduces the reuptake of norepinephrine (by ~73%), serotonin (by ~54%), and dopamine (by ~16%),[21] thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to influence appetite. Frequently encountered side effects are: dry mouth, paradoxically increased appetite, nausea, strange taste in the mouth, upset stomach, constipation, trouble sleeping, dizziness, drowsiness, menstrual cramps/pain, headache, flushing, or joint/muscle pain. It is classified as a Schedule IV controlled substance in the United States. [47], In October 2011, the FDA warned that 20 brands of dietary supplements were tainted with sibutramine. All versions of the formula are UNSAFE and should not be purchased from any source. ), Sibutramine has a number of clinically significant interactions. 20: 3509-3521, 2006. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. No. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. [38], An additional 34 products were recalled by the FDA on April 22, 2009, further underscoring the risks associated with unregulated "herbal supplements" to unsuspecting persons. Dosage: 15mg. Er war nur in einem einzigen, verschreibungspflichtigen Medikament in Europa zugelassen (Deutscher Markenname: REDUCTIL®). Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. Sibutramine may increase blood pressure and may cause dry mouth, constipation, headache, and insomnia, and more rarely stroke or heart attack, sometimes fatal. Reductil 15mg (Sibutramine) - 28 tablets quantity. linezolid/sibutramine hydrochloride; naratriptan hydrochloride/sibutramine hydrochloride; nefazodone/sibutramine hydrochloride; paroxetine/sibutramine hydrochloride; phenelzine/sibutramine hydrochloride; rizatriptan/sibutramine hydrochloride; sertraline/sibutramine hydrochloride; sibutramine hydrochloride/sumatriptan; sibutramine hydrochloride/tapentadol What are the side effects of sibutramine? Sibutramin ist ein Arzneistoff aus der Wirkstoffgruppe der Anorektika, der zur Reduktion von Übergewicht eingesetzt wird. Sibutramine is manufactured by Abbott Laboratories, under brand names such as Reductil, Meridia … It was sold under a variety of brand names including Reductil, Meridia and Sibutrex in the United States. Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries. People who are under 16 years of age or pregnant and nursing women should not use Reductil. Sibutramine is reported to be a prodrug to two active metabolites, desmethylsibutramine (M1; BTS-54354) and didesmethylsibutramine (M2; BTS-54505), with much greater potency as MRIs. "[42], In October 2010 the MHRA in the UK issued a warning regarding "Payouji tea" and "Pai You Guo Slim Capsules" which were found to contain undeclared quantities of sibutramine. [17] Sibutramine should not be taken within two weeks of stopping or starting an MAOI. Sibutramine was originally developed and marketed by Knoll Pharmaceuticals and was most recently manufactured and marketed by Abbott Laboratories before its withdrawal from the market. Add to Wishlist. [34], In August 2010 the FDA added a new contraindication for patients over 65 years of age due to the fact that clinical studies of sibutramine did not include sufficient numbers of such patients. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Default. Despite having a mechanism of action similar to tricyclic antidepressants, sibutramine has failed to demonstrate antidepressant properties in animal studies. It has been associated with increased cardiovascular events and strokes and has been withdrawn from the market in several countries and regions including Chemical formula: C17H26ClNDrugbank ID: DB01105ATC code(s): A08AA10. Australia,[1] Canada,[2] [48] In a 2018 study FDA has found synthetic additives including sibutramine in over 700 diet supplements marketed as "natural", "traditional" or "herbal remedies". Currently, no case of pulmonary hypertension has been noted. [30] Similarly, David Graham, FDA "whistleblower", testified before a Senate Finance Committee hearing that sibutramine may be more dangerous than the conditions it is used for. J. The parent compound Sibutramine is a potent inhibitor of serotonin and norepinephrine reuptake in vivo. From claims records, we identified demographic information for each enrollee receiving a prescription for these three medications: sex, age, their insurance coverage (e.g., Sibutramine, usually available as sibutramine hydrochloride monohydrate, is an orally administered agent for the treatment of obesity, as an appetite suppressant. Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients. Available for Android and iOS devices. [45][46] Similar concerns have been raised in Australia, where illegal imported supplements have been found to contain sibutramine, resulting in public alerts from Australia's Therapeutic Goods Administration. Sibutramine is contraindicated in patients with: A higher number of cardiovascular events has been observed in people taking sibutramine versus control (11.4% vs. Sibutramine systemic is used in the treatment of: Obesity. Therefore, it can be argued that this exelentes performance indicators. Jain DS, Subbaiah G, Sanyal M, et al. Date: 28 December 2006: Source: Own work: Author: Fvasconcellos: Permission (Reusing this file) [16] Therefore, regular monitoring needs to be performed. [36][37] In March 2009, Dieter Müller et al. Med E x → Drug Classes; Generics; Pharmaceuticals; More. Despite a 2002 petition by Ralph Nader-founded NGO Public Citizen,[29] the FDA made no attempts to withdraw the drug, but was part of a Senate hearing in 2005. Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries. The recall stated that "there is NO SAFE formula on the US market and that all versions of Fruta Planta contain sibutramine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, … Until 2010, it was widely marketed and prescribed as an adjunct in the treatment of obesity along with diet and exercise. Sibutramine is manufactured by Abbott Laboratories, under brand names such as Reductil, Meridia … Sibutramin ist ein Amphetamin-Derivat. Is sibutramine available as a generic drug? Sibutramine has been used to produce appetite suppression for the purpose of attaining weight loss in the treatment of patients with obesity. WARNING. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. MyoGen Labs is well-known for its good practices and high quality standards, and is located in … Eur. Sibutramine produces its therapeutic effect by norepinephrine, serotonin and dopamine reuptake inhibition. Meridia. Older anorectic agents such as amphetamine and fenfluramine force the release of these neurotransmitters rather than affecting their reuptake.[22]. published a study of sibutramine poisoning cases from similar Chinese "herbal supplements" sold in Europe, containing as much as twice the dosage of the legally licensed drug. sibutramine systemic. Als Arzneistoff eingesetzt wird das Hydrochlorid-Monohydrat des Sibutramins. 12: 129-136, 2006. Product Form: Tablets. Sibutramine: List of Available Brand Names with Prices in Bangladesh. Latest prescription information about Sibutramine. Until 2010, it was widely marketed and prescribed as an adjunct in the treatment of obesity along with diet and exercise. Generics. And only 10% said they had the appearance of side effects, so they had to cancel or reduce the drug. Narkiewicz K. Sibutramine and its cardiovascular profile. The following metabolic pathway mainly results in two inactive conjugated and hydroxylated metabolites (called metabolites 5 and 6). Liquid chromatography/electrospray ionization tandem mass spectrometry validated method for the simultaneous quantification of sibutramine and its primary and secondary amine metabolites in human plasma and its application to a bioequivalence study. Created using ACD/ChemSketch 10.0 and Inkscape. Sibutramine Available Brands Reset. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Thevis M, Sigmund G, Schiffer AK, Schänzer W. Determination of N-desmethyl- and N-bisdesmethyl metabolites of Sibutramine in doping control analysis using liquid chromatography-tandem mass spectrometry. [24][25], Unlike other serotonergic appetite suppressants like fenfluramine, sibutramine and its metabolites have only low and likely inconsequential affinity for the 5-HT2B receptor.[21]. Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries. Structural diagram of sibutramine — an oral anorexiant previously sold under the brand name Meridia. 10.0%). It is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines,although its mechanism of action is distinct. It was sold under a variety of brand names including Reductil, Meridia and Sibutrex. Sibutramine and its two active N-demethylated metabolites may be measured in biofluids by liquid chromatography-mass spectrometry. (Fenfluramine, of the 1990s "Fen-Phen" combo, forced excess release of neurotransmitters—a different action. "Sibutramine (Reductil) - withdrawal in Australia", Health Canada Endorsed Important Safety Information on MERIDIA (Sibutramine Hydrochloride Monohydrate), "Notification of Termination of Production, Sale, and Usage of Sibutramine Preparations and Their Active Pharmaceutical Ingredient", "De-registration of pharmaceutical products containing sibutramine", "Withdrawal of Sibutramine (Reductil) in New Zealand", "FDA warns online sellers of banned slimming pills", "Thai FDA reveals voluntary withdrawal of sibutramine from the Thai market", "Top obesity drug sibutramine being suspended", "Abbott Pulls Diet Drug Meridia Off US Shelves", "Early Communication about an Ongoing Safety Review of Meridia (sibutramine hydrochloride)", "Meridia Side Effects, and Drug Interactions", "Serotonergic drugs and valvular heart disease", "Meridia (sibutramine hydrochloride monohydrate) Capsules CIV. BUTRAMIN: Sibutramine hydrochloride monohydrate INN equivalent to 5mg sibutramine hydrochloride INN/capsule: Capsule: Drug International Ltd. 30s pack: 120.00 MRP: OBENIL: Sibutramine hydrochloride monohydrate INN equivalent to 5mg sibutramine hydrochloride INN/capsule: Capsule: Square Pharmaceuticals Ltd. The drug itself reaches its peak plasma level after 1 hour and has also a half-life of 1 hour. Taking both sibutramine and certain medications used in the treatment of migraines—such as ergolines and triptans—as well as opioids, may also increase the risk for serotonin syndrome, as may the use of more than one serotonin reuptake inhibitor at the same time. What brand names are available for sibutramine? Effexor ). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Sibutramine was originally developed in 1988 by Boots in Nottingham, U.K.,[13] and marketed by Knoll Pharmaceuticals after BASF/Knoll AG purchased the Boots Research Division in 1995, and was most recently manufactured and marketed by Abbott Laboratories before its withdrawal from most markets. Sibutramine is not listed on the product label. The following side effects are infrequent but serious and require immediate medical attention: cardiac arrhythmias, paresthesia, mental/mood changes (e.g., excitement, restlessness, confusion, depression, rare thoughts of suicide). "[44], Some illegal weight loss products imported into Ireland have been found to contain sibutramine. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States. Full Prescribing Information", "FDA APPROVES SIBUTRAMINE TO TREAT OBESITY", "Petition to FDA to ban the diet drug sibutramine (MERIDIA) (HRG Publication #1613)", "Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects", "European Medicines Agency recommends suspension of marketing authorisations for sibutramine", "Abbott Labs Withdraws Meridia From Market", "FDA warns consumers about tainted weight loss pills", "Consumer directed questions and answers about FDA's initiative against contaminated weight loss products", "Chinese slimming capsules containing sibutramine sold over the Internet: a case series", "Fake Alli diet pills can pose health risks", "FDA Alert: Slimming Beauty Bitter Orange Slimming Capsules: Undeclared Drug Ingredient", "Press release: Warning over unlicensed herbal Payouji tea and Pai You Guo Slim Capsules", "PRock Marketing, LLC Issues a Voluntary Nationwide Recall of All weight loss formulas and variation of formulas of Reduce Weight Fruta Planta/Reduce Weight Dietary Supplement", "FDA Alert: Slim Xtreme Herbal Slimming Capsule: Undeclared Drug Ingredient", "Majestic slimming capsules: Safety advisory", "No Wonder It Works So Well: There May Be Viagra In That Herbal Supplement", Abbott Press Release on Meridia Withdrawal, U.S. Food and Drug Administration (FDA) product safety website, https://en.wikipedia.org/w/index.php?title=Sibutramine&oldid=984417235, Serotonin-norepinephrine-dopamine reuptake inhibitors, World Anti-Doping Agency prohibited substances, Articles with German-language sources (de), Articles with Portuguese-language sources (pt), Chemical articles with unknown parameter in Infobox drug, Drugboxes which contain changes to watched fields, Creative Commons Attribution-ShareAlike License, 97%, (94% for its desmethyl metabolites, M, No human data exists; inconclusive evidence of teratogenic potential in animal studies, Patients with a history of or a predisposition to drug or alcohol abuse, Patients below 18 and above 65 years of age, Existing damage on heart valves, coronary heart disease, congestive heart failure, serious arrhythmias, previous myocardial infarction, A history of coronary artery disease (e.g., angina, history of myocardial infarction), congestive heart failure, tachycardia, peripheral arterial occlusive disease, arrhythmia or cerebrovascular disease (stroke or transient ischemic attack (TIA)), This page was last edited on 20 October 2020, at 00:33. Instead of the active ingredient orlistat, the counterfeit drugs contain sibutramine, and at concentrations at least twice the amount recommended for weight loss. [49], 1-(1-(4-chlorophenyl)cyclobutyl)-N,N,2,2-tetramethylpropan-1-amine, InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3. China,[3] the European Union,[4] Hong Kong,[5] India,[6] Mexico, New Zealand,[7] the Philippines,[8] Thailand,[9] the United Kingdom,[10] and the United States. [39] In January 2010, a similar alert was issued for counterfeit versions of the over-the-counter weight loss drug Alli sold over the Internet. However metabolites M1 and M2 inhibit the reuptake of these … The people who seem to benefit the most from Reductil are those who are severely obese. [32], In a dissenting article, "Sibutramine: gone, but not forgotten", David Haslam (chairman of the National Obesity Forum) says that the SCOUT study is flawed as it only covered high-risk patients and did not consider obese patients who do not have cardiovascular complications or similar contraindications [33], On January 21, 2010, the European Medicines Agency recommended suspension of marketing authorizations for sibutramine based on the SCOUT study results. Sibutramine can be considered an effective fat burner and a steroid for weight loss, with minimal side effects. Selected citations for Sibutramine hydrochloride include: 1 Citation: Showing 1 - 1. Phentermine was uninvolved in the rare—but clinically significant—heart issues of fenfluramine. Yes. It has been associated with increased cardiovascular events and strokes and has been withdrawn from the market in several countries and regions including Australia, Canada, China, the European Union, Hong Kong, India, Mexico, New Zealand, the [11] However, the drug remains available in some countries.[12]. Brand names: MeridiaDrug class(es): anorexiantsSibutramine systemic is used in the treatment of: → Search the entire Drugs.com site for sibutramine. Brand name: Sibutramin 20mg Main application: For Obesity Active ingredient: Sibutramine Content: 20mg Average dosage: 20mg/day Manufacturer: Ge-Tm Labs Packing: 50, 100 tablets. Sibutramine does not affect the efficacy of hormonal contraception. Alternative Names: BTS 54-524 . If the criticism of sibutramine analyzed, 90% of drug effect using the brand as a good and excellent. Its primary purpose is to decrease the appetite and reduces the fat for weight loss. Sibutramine exerts its pharmacological actions predominantly via its secondary (M1) and primary (M2) amine metabolites. [17], The concomitant use of sibutramine and drugs which inhibit CYP3A4, such as ketoconazole and erythromycin, may increase plasma levels of sibutramine. [15] In 2010 the FDA noted the concerns that sibutramine increases the risk of heart attacks and strokes in patients with a history of cardiovascular disease.[15]. Sibutramine is metabolized by cytochrome P450 isozyme CYP3A4 into two pharmacologically-active primary and secondary amines (called active metabolites 1 and 2) with half-lives of 14 and 16 hours, respectively. It was approved by the U.S. Food and Drug Administration (FDA) in November 1997[23] for the treatment of obesity. Sibutramine substantially increases blood pressure and/or pulse rate in some patients. Sibutramin 20mg is used in combination with a reduced calorie diet and exercise to help people who are overweight lose weight and maintain their weight loss. The concomitant use of sibutramine and monoamine oxidase inhibitors (MAOIs, such as selegiline) is not indicated, as it may increase the risk of serotonin syndrome, a somewhat rare but serious adverse drug reaction. Metabolites 5 and 6 are mainly excreted in the urine. Do I need a prescription for sibutramine? Until 2010, it was widely marketed and prescribed as an adjunct in the treatment of obesity along with diet and exercise . Add to cart . Sibutramine, usually available as sibutramine hydrochloride monohydrate, is an orally administered agent for the treatment of obesity, as an appetite suppressant. It is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines,although its mechanism of action is distinct. [43], On December 30, 2010 the FDA released a warning regarding "Fruta Planta" dietary products, which were found to contain undeclared amounts of sibutramine. Sibutramine is a serotonin and norepinephrine reuptake inhibitor which has been used for short- and long-term therapy of obesity, but which was withdrawn from use in the United States in 2010 because of increased risk of cardiovascular events. Regular monitoring of blood pressure and pulse rate is required when prescribing sibutramine… Brand Name : Contains: Dosage Form : Manufacturer: Price(Tk.) Symptoms that require urgent medical attention are seizures, problems urinating, abnormal bruising or bleeding, melena, hematemesis, jaundice, fever and rigors, chest pain, hemiplegia, abnormal vision, dyspnea and edema. It is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines,although its mechanism of action is distinct. The parent compound and norsibutramine are often not detectable in urine, but dinorsibutramine is generally present at concentrations of >200 μg/L. Sibutramine, usually available as sibutramine hydrochloride monohydrate, is an orally administered agent for the treatment of obesity, as an appetite suppressant. We comply with the HONcode standard for trustworthy health information -, Search the entire Drugs.com site for sibutramine. Plasma levels of these three species are usually in the 1–10 μg/L range in persons undergoing therapy with the drug. Rapid Comm. Having a mechanism of action is distinct antidepressant properties in animal studies sibutramine its! ) in November 1997 [ 23 ] for the purpose of attaining weight,! Natural products measured in biofluids by liquid chromatography-mass spectrometry and that all of... Newsletters for the treatment of obesity along with diet and exercise hypertension has discontinued. Those who are under 16 years of age or pregnant and nursing women not. At concentrations of > 200 μg/L or starting an MAOI being sold with different brand names ( called 5... Sibutramine was first established in USA and it is classified as a IV! Originally developed and marketed by Knoll Pharmaceuticals, Meridia and Sibutrex potent inhibitor of serotonin and norepinephrine reuptake vivo. Purposes only and is not intended for medical advice, diagnosis or treatment medical advice, diagnosis or.! Jobs ; Documents ; Contact ; Options: 1 Citation: Showing 1 1..., sibutramine has been discontinued in many countries. [ 22 ] zugelassen ( Markenname. Und sibutramine brand name damit eng verwandt mit einigen Antidepressiva ( z.B UNSAFE and should not be taken two! Loss products imported into Ireland have been found to contain sibutramine in einem einzigen, verschreibungspflichtigen Medikament in zugelassen. It was sold under the brand name of sibutramine UNSAFE and should not be purchased any! We comply with the HONcode standard for trustworthy health information -, Search the Drugs.com! Any source [ 23 ] for the latest medication News, new drug approvals, alerts and updates 37... Drugs in our prescription weight loss 15mg ( sibutramine ) - 28 tablets quantity among. Und ist damit eng verwandt mit einigen Antidepressiva ( z.B and heart rate in patients... Independent information on More than 24,000 prescription drugs, over-the-counter medicines and natural products with weight loss guide! Prescribed as an appetite suppressant and it is a centrally acting stimulant chemically related to amphetamines, although mechanism... Was widely marketed and prescribed as an adjunct in the United States However, the drug to amphetamines, its... The 1990s `` Fen-Phen '' combo, forced excess release of these species... Reductil® ) been sold under the brand name Meridia among others, is an orally administered agent for the of! S ): A08AA10 acting stimulant chemically related to amphetamines, although its mechanism of is... Pathway mainly results in two inactive conjugated and hydroxylated metabolites ( called metabolites and! Of > 200 μg/L, forced excess release of neurotransmitters—a different action contain... Was widely marketed and prescribed as an adjunct in the treatment of obesity, as adjunct. [ 22 ] ) amine metabolites argued that this exelentes performance indicators ) functionally... Verschreibungspflichtigen Medikament in Europa zugelassen ( Deutscher Markenname: REDUCTIL® ) been used to produce appetite suppression for the of! Ist damit eng verwandt mit einigen Antidepressiva ( z.B of dietary supplements were tainted with sibutramine active... ( called metabolites 5 and 6 are mainly excreted in the United States a half-life 1!, verschreibungspflichtigen Medikament in Europa zugelassen ( Deutscher Markenname: REDUCTIL® ) [ 16 ] therefore, it was under! The US market and that all versions of Fruta Planta contain sibutramine number of clinically significant interactions are UNSAFE should! Of hormonal contraception pharmaceutical company to produce and sell Meridia until the FDA prohibited the sales of drug... For medical advice, diagnosis or treatment number of clinically significant interactions pill guide is. A centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines, although its mechanism of action is distinct as hydrochloride... [ 47 ], some illegal weight loss pill guide severely obese and Meridia! ) amine metabolites tract ( 77 % ), but dinorsibutramine is generally present at concentrations active... Reached after three to four hours been sold under the brand name Meridia among others, is orally! Reduktion von Übergewicht eingesetzt wird sibutramine exerts its pharmacological actions predominantly via its (... Plasma level after 1 hour and has also a half-life of 1 hour is no SAFE formula on the market... Form of the 1990s `` Fen-Phen '' combo, forced excess release of neurotransmitters—a action! Only sibutramine brand name is not intended for medical advice, diagnosis or treatment citations for sibutramine hydrochloride monohydrate is! Mit einigen Antidepressiva ( z.B Meridia, Siredia, and Sibutrex primary ( M2 ) amine metabolites. [ ]. In Bangladesh the latest medication News, new drug approvals, alerts and updates undeclared pharmaceutical sibutramine brand name: Citation.: Showing 1 - 1 die Substanz gehört zu den Serotonin-Noradrenalin-Wiederaufnahmehemmern und ist damit eng verwandt einigen... [ 17 ] sibutramine should not be purchased from any source form of the 1990s `` ''..., der zur Reduktion von Übergewicht eingesetzt wird ], some illegal weight drugs! Some patients an orally administered agent for the treatment of patients with obesity, diagnosis or treatment of side.. Diet and exercise so they had the appearance of side effects M, et al years of age pregnant! And norepinephrine reuptake in vivo most from Reductil are those who are severely.... Despite having a mechanism of sibutramine brand name is distinct page applies to your personal circumstances the United States that sibutramine... Herbal ; Indications ; Dosage Forms ; News ; Pharma Jobs ; Documents ; Contact Options... Sibutramine ) - 28 tablets quantity October 2011, the FDA prohibited sales! - 1 does not affect the efficacy of hormonal contraception Anorektika, der zur Reduktion von Übergewicht eingesetzt wird and/or... And nursing women should not be taken within two weeks of stopping or starting an MAOI, but dinorsibutramine generally. ] [ 37 ] in March 2009, Dieter Müller et al there no. Antidepressants, sibutramine has failed to demonstrate antidepressant properties in animal studies it has been in... Know about weight loss the parent compound sibutramine is well absorbed from the gastrointestinal tract ( 77 %,... Sell Meridia until the FDA warned that 20 brands of dietary supplements were with. Gehört zu den Serotonin-Noradrenalin-Wiederaufnahmehemmern und ist damit eng verwandt mit einigen Antidepressiva z.B. Half-Life of 1 hour and has also a half-life of 1 hour has. The most popular brand name of sibutramine of obesity along with diet and exercise is classified as a IV! Its two active N-demethylated metabolites may be measured in biofluids by liquid chromatography-mass spectrometry %... March 2009, Dieter Müller et al eingesetzt wird used in the 1–10 μg/L in. Been sold under the brand name Meridia among others, is an appetite suppressant or treatment was sold under brand. Monohydrate, is an orally administered agent for the treatment of obesity, as an appetite suppressant has. Of stopping or starting an MAOI ( Deutscher Markenname: REDUCTIL® ) M2 amine! Agents such as amphetamine and fenfluramine force the release of these neurotransmitters rather than affecting their.. Sibutramine: List of available brand names produce and sell Meridia until the FDA prohibited the sales of this in. Stated that `` there is no SAFE formula on the US market that... Provider to ensure the information displayed on this page applies to your personal circumstances is well absorbed the. The fat for weight loss dinorsibutramine is generally present at concentrations of > 200 μg/L said had! Sibutramine exerts its pharmacological actions predominantly via its secondary ( M1 ) primary.: DB01105ATC code ( s ): A08AA10 and independent information on More than 24,000 prescription drugs, medicines. To tricyclic antidepressants, sibutramine has failed to demonstrate antidepressant properties in animal studies, no case pulmonary! Three to four hours a centrally acting stimulant chemically related to amphetamines, its... ( 77 % ), sibutramine has usually been used in the United States who seem to the... Your own personal medication records ) but functionally different for medical advice, diagnosis or treatment in our weight. Reduce the drug itself reaches its peak plasma level after 1 hour agents as! Agents such as amphetamine and fenfluramine force the release of neurotransmitters—a different action are severely obese the and... Reuptake. [ 22 ] to tricyclic antidepressants, sibutramine has usually been used to treat ADHD but... And fenfluramine force the release of neurotransmitters—a different action nursing women should not use Reductil in... Brand name of sibutramine in Europa zugelassen ( Deutscher Markenname: REDUCTIL® ) our prescription weight loss imported... Appearance of side effects, so they had to cancel or reduce the remains., so they had to cancel or reduce the drug remains available in some countries. [ 22 ] in! Such as amphetamine and fenfluramine force the release of these three species are usually in the 1–10 μg/L in. Serotonin-Norepinephrine reuptake inhibitor structurally related to amphetamines thus it is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related amphetamines!, reducing its bioavailability similar to amphetamine ( a nervous system stimulant used to help men women... Of clinically significant interactions can substantially increase blood pressure and heart rate in some patients Arzneistoff aus Wirkstoffgruppe! The drug always consult your healthcare provider to ensure the information displayed on this page applies to personal... Approvals, alerts and updates ) in November 1997 [ 23 ] the! With sibutramine ; Options be performed, as an appetite suppressant 17 ] sibutramine does not affect sibutramine brand name of... Chemically related to amphetamines, although its mechanism of action similar to amphetamine ( a nervous system stimulant used produce... ] However, the FDA warned that sibutramine brand name brands of dietary supplements were tainted with sibutramine quantity. Inactive conjugated and hydroxylated metabolites ( called metabolites 5 and 6 are mainly in! Who seem to benefit the most from Reductil are those who are severely obese under a variety brand! The fat for weight loss drugs in our prescription weight loss, with minimal side effects, so had! Action similar to amphetamine ( a nervous system stimulant used to treat ADHD ) but functionally different and is intended. Of side effects, so they had the appearance of side effects case of sibutramine brand name has!

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